CD117/CD34 Expression in Leukemic Blasts

Lipid Mediators and Human Leukemic Blasts

Some of the most potent inflammatory mediators share a lipid origin. They regulate a wide spectrum of cellular processes including cell proliferation and apoptosis. However, the precise roles and ways (if any) in which these compounds impact the growth and apoptosis of leukemic blasts remain incompletely resolved. In spite of this, significant advances have been recently made. Here we briefly r...

in vitro evaluation of cytarabin induced apoptosis in leukemic blasts

apoptosis, or active cell death, is a specific mode of cell death, which is characterized by morphological changes such as chromatin condensation, fragmentation of the nucleus, cytoplasmic retraction and appearance of apoptotic bodies' containing apparently intact organelles. apoptosis occurs in physiological conditions as a regulatory mechanism of tissue growth, where cell proliferation is bal...

Class II-associated invariant chain peptide expression on myeloid leukemic blasts predicts poor clinical outcome.

Effective antitumor responses need the activation of CD4+ T cells. MHC class II antigen presentation requires the release of class II-associated invariant chain peptide (CLIP) from the antigen-binding site. In antigen-presenting cells, human leukocyte antigen DM (HLA-DM; abbreviated DM in this article) catalyzes CLIP dissociation. In B cells, HLA-DO (DO) down-modulates DM function. Cell surface...

Leukemic Blasts From Patients With Acute Myeloid Leukemias

A CUTE LEUKEMIAS are regarded as disorders characterized by a diffenentiative block of the hemopoietic precursors, which results in an unnegulated accumulation of immature blood cells.”2 Several in vitro experiments have shown that this block can be overcome by a wide variety ofchemical compounds;”3 based on these reports, new strategies of treatment have been proposed for leukemia therapy. Suc...

Patterns of Gelatinase-B Expression in Leukemic Cell Lines